A practical solution-phase synthesis of an antagonistic peptide of TNF-α based on hydrophobic tag strategy.
نویسندگان
چکیده
A simple acid-resistant hydrophobic tag, which can be removed rapidly in a single-step procedure after overall peptide synthesis, has been developed to accomplish practical solution-phase synthesis of a 15-mer antagonistic peptide of TNF-α (A-TNF-α). Hydrophobically tagged peptides can be separated as precipitates at each step by addition of a polar organic solvent.
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عنوان ژورنال:
- Chemical communications
دوره 46 43 شماره
صفحات -
تاریخ انتشار 2010